The 2008 highlights in cardiovascular and thoracic anesthesia include the ultimate departure of aprotinin from clinical practice. However, a new antihypertensive drug, clevidipine, was approved for perioperative control of hypertension. There were also advances in pharmacologic myocardial conditioning with agents such as cyclosporine, sodium nitroprusside, and levosimendan. Furthermore, ischemic preconditioning appears ready for testing in large clinical trials designed to improve ischemic outcomes after cardiac surgery. With regard to transfusion, a landmark study suggests that transfused red blood cells stored for >2 weeks may significantly worsen major outcome after cardiac surgery. Furthermore, a second study suggests that relative rather than absolute hemoglobin reduction significantly determines adverse outcomes after cardiac surgery. These studies may greatly affect future transfusion guidelines. Left-sided valve replacement has been revolutionized by transcatheter technology, which progressed significantly in 2008. Important advances in percutaneous coronary intervention included drug-eluting bioabsorbable stents and further insights into the clinical consequences of platelet resistance. These 2008 themes represent a sampling of the total highlights for the year. Many of the advances not covered have been reviewed and discussed in the literature review sections of the Journal in 2008.