Nonglycosidic agonists of invariant NKT cells for use as vaccine adjuvants

ChemMedChem. 2009 Feb;4(2):171-5. doi: 10.1002/cmdc.200800354.

Abstract

Based on the crystal structures of human alpha-GalCer-CD1d and iNKT-alpha-GalCer-CD1d complexes, nonglycosidic analogues of alpha-GalCer were synthesized. They activate iNKT cells resulting in dendritic cell maturation and the priming of antigen-specific T and B cells. Therefore, they are attractive adjuvants in vaccination strategies for cancer and infectious diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Immunologic / chemistry
  • Adjuvants, Immunologic / pharmacology*
  • Animals
  • Cell Line
  • Glycosides / chemistry*
  • Humans
  • Killer Cells, Natural / drug effects*
  • Killer Cells, Natural / immunology
  • Mice
  • Vaccines / immunology*

Substances

  • Adjuvants, Immunologic
  • Glycosides
  • Vaccines