Resting heart rate does not reflect the degree of beta-blockade in subjects with heart failure on chronic beta-blocker therapy

Cardiovasc Ther. 2009 Spring;27(1):42-8. doi: 10.1111/j.1755-5922.2009.00072.x.

Abstract

We investigated the relationship between resting heart rate (HR) and two measures of beta-1 receptor sensitivity/blockade: (1) the percentage of maximal predicted heart rate reached during exercise (%MPHR), and (2) the HR increase per unit of circulating norepinephrine (NE) or the chronotropic responsiveness index (CRI) in 28 patients with systolic CHF on chronic beta-blocker therapy. Our results show that resting HR is not associated with HR response during exercise nor with beta-1 receptor sensitivity to circulating NE.

MeSH terms

  • Adrenergic beta-1 Receptor Antagonists*
  • Adrenergic beta-Antagonists / therapeutic use*
  • Adult
  • Biomarkers / blood
  • Chronic Disease
  • Exercise Test
  • Exercise Tolerance / drug effects*
  • Female
  • Heart Failure / drug therapy*
  • Heart Failure / metabolism
  • Heart Failure / physiopathology
  • Heart Rate / drug effects*
  • Humans
  • Male
  • Middle Aged
  • Norepinephrine / blood
  • Practice Guidelines as Topic
  • Treatment Outcome

Substances

  • Adrenergic beta-1 Receptor Antagonists
  • Adrenergic beta-Antagonists
  • Biomarkers
  • Norepinephrine