Abstract
Transcriptional responses of microorganisms to environmental perturbations are broad and complex, and often involve regulatory cascades in which an interplay of regulatory factors trigger a specific expression program. Here, we describe how Pseudomonas responds to challenges from toxic chemicals, for which they use a dedicated program that subsequently confers resistance to these compounds. A mosaic of domains has been recruited to sense and metabolize these chemicals in order to obtain energy and carbon.
MeSH terms
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Bacterial Proteins / metabolism
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DNA-Binding Proteins / metabolism
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Environmental Pollutants / metabolism*
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Environmental Pollutants / toxicity
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Hydrocarbons, Aromatic / metabolism
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Hydrocarbons, Aromatic / toxicity
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Protein Kinases / metabolism
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Pseudomonas putida / drug effects
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Pseudomonas putida / metabolism*
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Signal Transduction / drug effects
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Signal Transduction / physiology*
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Transcription Factors / metabolism
Substances
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Bacterial Proteins
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DNA-Binding Proteins
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Environmental Pollutants
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Hydrocarbons, Aromatic
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Transcription Factors
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XylR protein, Pseudomonas
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Protein Kinases
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TodS protein, Pseudomonas putida