The Severity of Dependence Scale detects people with medication overuse: the Akershus study of chronic headache

J Neurol Neurosurg Psychiatry. 2009 Jul;80(7):784-9. doi: 10.1136/jnnp.2008.168864. Epub 2009 Mar 11.

Abstract

Objective: To evaluate the Severity of Dependence Scale (SDS) in people with primary chronic headache and analyse the pattern of medication overuse.

Design: Cross sectional epidemiological survey. A posted questionnaire screened for chronic headache. Neurological residents interviewed those with self-reported chronic headache. The International Classification of Headache Disorders was used. Split file methodology was employed for data analysis.

Setting: Akershus University Hospital, Oslo, Norway.

Participants: A random sample of 30,000 people, aged 30-44 years, from the general population of Akershus County, Norway. 405 people had primary chronic headache.

Main outcome measure: SDS score in those with and without medication overuse.

Results: The screening questionnaire response rate was 71% and the participation rate of the interview 74%. Among 405 people with primary chronic headache, 95% had chronic tension-type headache, 4% had chronic migraine and <1% had other primary chronic headaches. Of 386 persons with chronic tension-type headache, 44% had medication overuse and 47% had co-occurrence of migraine. Simple analgesics, combination analgesics, triptans, ergotamine, opioids and a combination of acute medications were overused by 65%, 27%, 4%, <1%, 1% and 2% of people, respectively. The mean SDS score was significantly higher in those with than in those without medication overuse (5.6 vs 2.7; p<0.001).

Conclusion: The SDS questionnaire detects medication overuse and dependency-like behaviour in persons with primary chronic headache.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analgesics / administration & dosage
  • Analgesics / adverse effects*
  • Analgesics, Opioid / administration & dosage
  • Analgesics, Opioid / adverse effects*
  • Analysis of Variance
  • Comorbidity
  • Cross-Sectional Studies
  • Drug Therapy, Combination
  • Ergotamine / administration & dosage
  • Ergotamine / adverse effects*
  • Female
  • Headache Disorders / drug therapy*
  • Headache Disorders / epidemiology*
  • Headache Disorders / psychology
  • Humans
  • Male
  • Migraine Disorders / drug therapy
  • Migraine Disorders / epidemiology
  • Norway / epidemiology
  • Severity of Illness Index
  • Substance-Related Disorders / epidemiology*
  • Substance-Related Disorders / etiology
  • Substance-Related Disorders / psychology
  • Surveys and Questionnaires
  • Tension-Type Headache / drug therapy
  • Tension-Type Headache / epidemiology
  • Treatment Outcome
  • Tryptamines / administration & dosage
  • Tryptamines / adverse effects*

Substances

  • Analgesics
  • Analgesics, Opioid
  • Tryptamines
  • Ergotamine