The G72/G30 (D-amino-acid oxidase activator) complex was the first gene to be associated with bipolar disorder (BPD) in European populations, but until now no such association has been identified in Asian populations. To investigate possible association in the Chinese Han population, we carried out a study involving 475 BPD patients and 588 healthy controls. The results provide first evidence for the single nucleotide polymorphism rs778293 in G72 as a potential candidate in altering risk for BPD in the Chinese Han population.