Is factor V Leiden mutation a cause of in vitro fertilization failure?

Fertil Steril. 2009 Oct;92(4):1256-1259. doi: 10.1016/j.fertnstert.2009.03.089. Epub 2009 May 21.

Abstract

This prospective cohort study tested whether the most common hereditary thrombophilia, factor V Leiden (FVL) mutation, is associated with nonpregnancy after IVF. Factor V Leiden mutation prevalence was very low (1.6%) and had a preliminarily positive association with pregnancy, suggesting that routine testing in a general IVF population for FVL mutation as a cause of IVF failure and infertility is not indicated.

Publication types

  • Clinical Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cohort Studies
  • Factor V / analysis
  • Factor V / genetics
  • Factor V / physiology*
  • Female
  • Fertilization in Vitro* / methods
  • Gene Frequency
  • Genetic Testing
  • Humans
  • Infertility, Female / blood
  • Infertility, Female / diagnosis
  • Infertility, Female / genetics
  • Infertility, Female / therapy
  • Mutation, Missense / physiology
  • Pregnancy
  • Prognosis
  • Treatment Failure
  • Young Adult

Substances

  • factor V Leiden
  • Factor V