Regulation of DGK-theta

J Cell Physiol. 2009 Sep;220(3):548-52. doi: 10.1002/jcp.21813.

Abstract

Diacylglycerol kinases are important regulators of lipid signaling and, consequently, important regulators of many diglyceride-dependent and PA-dependent proteins. Research over the last twenty years has clearly demonstrated that individual DGK isoforms can be connected with disparate cellular processes, indicating the presence of a sophisticated regulatory network for diglyceride and phosphatidic acid signaling through the regulation of individual DGK isoforms. This review presents the progress on the characterization of a primarily neuronal isoform DGK-theta, and examines current data on the primary structure, regulation and potential cellular functions of this enzyme.

Publication types

  • Review

MeSH terms

  • Animals
  • Diacylglycerol Kinase / chemistry
  • Diacylglycerol Kinase / genetics
  • Diacylglycerol Kinase / metabolism*
  • Diglycerides / metabolism
  • Enzyme Activation
  • Humans
  • Isoenzymes
  • Membrane Lipids / metabolism
  • Neurons / enzymology*
  • Neurotransmitter Agents / metabolism
  • Phosphatidic Acids / metabolism
  • Protein Binding
  • Protein Conformation
  • Protein Interaction Mapping
  • Signal Transduction*
  • Synaptic Transmission

Substances

  • Diglycerides
  • Isoenzymes
  • Membrane Lipids
  • Neurotransmitter Agents
  • Phosphatidic Acids
  • Diacylglycerol Kinase