Abstract
Calf brain and human platelet extracts purified by Bio-Gel P2 column chromatography contained substances that inhibited serotonin uptake and 3H-imipramine binding. Some of these endogenous substances were also recognized by rabbit antibodies produced against imipramine. The data suggest the possible existence of endogenous serotonin uptake modulators, which may possess a partial molecular structure similar to that identified by the antibodies.
MeSH terms
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Animals
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Antibodies*
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Blood Platelets / metabolism*
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Carrier Proteins*
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Cattle
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Frontal Lobe / metabolism*
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Humans
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Imipramine / immunology*
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Imipramine / pharmacokinetics
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Radioligand Assay
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Receptors, Drug*
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Receptors, Neurotransmitter / antagonists & inhibitors*
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Receptors, Neurotransmitter / metabolism
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Receptors, Serotonin / metabolism
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Serotonin / blood*
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Serotonin Antagonists*
Substances
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Antibodies
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Carrier Proteins
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Receptors, Drug
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Receptors, Neurotransmitter
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Receptors, Serotonin
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Serotonin Antagonists
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imipramine receptor
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Serotonin
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Imipramine