Dermatomyositis-like muscle pathology in patients with chronic graft-versus-host disease

Muscle Nerve. 2009 Oct;40(4):643-7. doi: 10.1002/mus.21353.

Abstract

Myositis is a rare complication of chronic graft-versus-host disease (cGVHD) following hematopoietic stem cell transplantation (HSCT). Almost all such patients have been reported to have polymyositis (PM). We describe clinical, pathologic, and molecular studies of 3 patients with cGVHD following allogeneic HSCT who developed myopathy. In each case, perifascicular atrophy, the pathognomonic histologic feature of dermatomyositis (DM), was observed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chronic Disease
  • Dermatomyositis / pathology*
  • Dermatomyositis / therapy
  • Electromyography
  • Exanthema / pathology
  • Female
  • Graft vs Host Disease / pathology*
  • Graft vs Host Disease / therapy
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Immunotherapy
  • Leukemia, Lymphocytic, Chronic, B-Cell / complications
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology
  • Leukemia, Lymphocytic, Chronic, B-Cell / therapy
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy
  • Leukemia, Myeloid, Acute / complications
  • Leukemia, Myeloid, Acute / pathology
  • Leukemia, Myeloid, Acute / therapy
  • Male
  • Muscle Weakness / etiology
  • Muscle, Skeletal / pathology*