Abstract
Myositis is a rare complication of chronic graft-versus-host disease (cGVHD) following hematopoietic stem cell transplantation (HSCT). Almost all such patients have been reported to have polymyositis (PM). We describe clinical, pathologic, and molecular studies of 3 patients with cGVHD following allogeneic HSCT who developed myopathy. In each case, perifascicular atrophy, the pathognomonic histologic feature of dermatomyositis (DM), was observed.
MeSH terms
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Adult
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Chronic Disease
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Dermatomyositis / pathology*
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Dermatomyositis / therapy
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Electromyography
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Exanthema / pathology
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Female
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Graft vs Host Disease / pathology*
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Graft vs Host Disease / therapy
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Hematopoietic Stem Cell Transplantation
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Humans
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Immunotherapy
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Leukemia, Lymphocytic, Chronic, B-Cell / complications
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Leukemia, Lymphocytic, Chronic, B-Cell / pathology
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Leukemia, Lymphocytic, Chronic, B-Cell / therapy
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy
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Leukemia, Myeloid, Acute / complications
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Leukemia, Myeloid, Acute / pathology
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Leukemia, Myeloid, Acute / therapy
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Male
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Muscle Weakness / etiology
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Muscle, Skeletal / pathology*