Using new tools to define the genetic underpinnings of risky traits associated with coronary artery disease: the SardiNIA study

Trends Cardiovasc Med. 2009 Apr;19(3):69-75. doi: 10.1016/j.tcm.2009.05.001.

Abstract

Genomewide association studies are increasingly being applied to search for novel genes that might underlie cardiovascular diseases. In this article, we briefly review the principles that underlie modern genetic analyses and provide several illustrations from the SardiNIA study of genomewide association studies for cardiovascular risk factor traits.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Blood Flow Velocity / genetics
  • Blood Glucose / genetics
  • Coronary Artery Disease / genetics*
  • Genetic Carrier Screening / methods*
  • Genetic Markers
  • Genome-Wide Association Study*
  • Genotype
  • Humans
  • Italy
  • Linkage Disequilibrium / genetics
  • Lipoproteins / genetics
  • Obesity / genetics
  • Polymorphism, Single Nucleotide / genetics*
  • Quantitative Trait, Heritable*
  • Uric Acid / blood

Substances

  • Blood Glucose
  • Genetic Markers
  • Lipoproteins
  • Uric Acid