Abstract
Nine of 17 patients with obsessive-compulsive disorder responded when neuroleptic was added to fluvoxamine with or without lithium. Comorbid occurrence of tic spectrum disorders or of schizotypal personality disorder was associated with response. Abnormalities in brain dopamine and serotonin may be implicated in such patients.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Antipsychotic Agents / therapeutic use*
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Drug Therapy, Combination
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Female
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Fluvoxamine
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Humans
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Lithium / therapeutic use
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Male
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Obsessive-Compulsive Disorder / complications
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Obsessive-Compulsive Disorder / drug therapy*
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Obsessive-Compulsive Disorder / psychology
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Oximes / therapeutic use*
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Schizotypal Personality Disorder / complications
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Schizotypal Personality Disorder / drug therapy
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Serotonin Antagonists / therapeutic use*
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Tic Disorders / complications
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Tic Disorders / drug therapy
Substances
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Antipsychotic Agents
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Oximes
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Serotonin Antagonists
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Lithium
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Fluvoxamine