Abstract
We investigated the effect of subcutaneous anti-D IgG as platelet enhancing therapy in children with idiopathic thrombocytopenic purpura (ITP). Twenty-three children were treated with subcutaneous anti-D 50 microg/kg. The median platelet count increased from 7 x 10(9) to 31 x 10(9)/L on day 3 (P < 0.01). The median decline in hemoglobin was 1.3 g/dl. Two children experienced minor fever and chills within 24 hr of treatment. Pain at the injection site was common but self-limiting with no effect on activity level. These results suggest subcutaneous anti-D IgG 50 microg/kg as an effective and well-tolerated treatment option in childhood ITP.
(c) 2009 Wiley-Liss, Inc.
Publication types
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Clinical Trial
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Multicenter Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Child
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Child, Preschool
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Chills / etiology
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Female
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Fever / etiology
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Hemoglobins / analysis
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Hemorrhage / etiology
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Humans
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Immunotherapy*
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Infant
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Injections, Subcutaneous
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Isoantibodies / administration & dosage
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Isoantibodies / adverse effects
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Isoantibodies / therapeutic use*
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Male
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Pain / etiology
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Platelet Count
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Prospective Studies
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Purpura, Thrombocytopenic, Idiopathic / blood
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Purpura, Thrombocytopenic, Idiopathic / complications
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Purpura, Thrombocytopenic, Idiopathic / therapy*
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Rho(D) Immune Globulin
Substances
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Hemoglobins
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Isoantibodies
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RHO(D) antibody
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Rho(D) Immune Globulin