T lymphocyte recognition of a celiac disease-associated cis- or trans-encoded HLA-DQ alpha/beta-heterodimer

J Immunol. 1990 Jul 1;145(1):136-9.

Abstract

The HLA-associated susceptibility to develop celiac disease may to a large extent be attributed to the combination of particular DQA1 and DQB1 genes, i.e., the DQA1*0501 and DBQB1*0201 alleles, located either in cis position (on the DR3DQw2 haplotype) or in trans position (DR5DQw7/DR7DQw2 heterozygous individuals). We report three alloreactive T lymphocyte clones that recognize an HLA-DQ alpha/beta heterodimer both when the DQA1*0501 and DQB1*0201 alleles are located in cis or in trans position. Thus, the celiac disease associated DQA1 and DQB1 genes encode a functionally expressed DQ alpha/beta heterodimer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Antibodies, Monoclonal / immunology
  • Base Sequence
  • CD4-Positive T-Lymphocytes / immunology*
  • Celiac Disease / immunology*
  • Cell Separation
  • Cloning, Molecular
  • HLA-DQ Antigens / genetics
  • HLA-DQ Antigens / immunology*
  • Humans
  • Lymphocyte Activation
  • Macromolecular Substances
  • Molecular Sequence Data
  • Oligonucleotide Probes

Substances

  • Antibodies, Monoclonal
  • HLA-DQ Antigens
  • Macromolecular Substances
  • Oligonucleotide Probes