Disinhibition due to disruption of the orbitofrontal circuit treated successfully with carbamazepine: a case series

J Neuropsychiatry Clin Neurosci. 2009 Summer;21(3):323-7. doi: 10.1176/jnp.2009.21.3.323.

Abstract

The frontal-subcortical pathways play a role in governing behavior. Injury may disrupt their functioning and produce neuropsychiatric symptoms. The authors discuss the kindling theory in the possible production of these symptoms, which significantly improved with the potent antikindling agent, carbamazepine.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain Diseases / complications
  • Brain Diseases / diagnostic imaging
  • Brain Diseases / drug therapy*
  • Carbamazepine / therapeutic use*
  • Female
  • Follow-Up Studies
  • Frontal Lobe* / diagnostic imaging
  • Frontal Lobe* / drug effects
  • Humans
  • Male
  • Mental Disorders / diagnostic imaging
  • Mental Disorders / drug therapy*
  • Mental Disorders / etiology
  • Middle Aged
  • Psychotropic Drugs / therapeutic use*
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • White People

Substances

  • Psychotropic Drugs
  • Carbamazepine