Abstract
Calprotectin is produced by activated monocytes and microglia, and cerebrospinal fluid (CSF) levels could be a marker of neuroinflammation. Calprotectin was detectable in CSF from 13.8% of normal controls, compared to 90.5% of patients with neurological infections (p<0.001). In CSF from patients with multiple sclerosis (MS) and clinically isolated demyelinating syndrome, calprotectin was detected in 64.7% within 2 weeks after symptom debut compared to 30.8% between 2 and 4 weeks and 17.0% thereafter (p<0.001). We conclude that CSF calprotectin reflects the disease activity in MS but does not discriminate between MS and other inflammatory or infectious conditions.
MeSH terms
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Adult
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Biomarkers / cerebrospinal fluid
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Central Nervous System / immunology
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Central Nervous System / physiopathology
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Cerebrospinal Fluid / chemistry
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Cerebrospinal Fluid / immunology
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Cerebrospinal Fluid / metabolism
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Diagnosis, Differential
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Encephalitis / cerebrospinal fluid*
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Encephalitis / diagnosis*
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Encephalitis / immunology
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Female
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Humans
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Leukocyte L1 Antigen Complex / analysis
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Leukocyte L1 Antigen Complex / cerebrospinal fluid*
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Male
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Microglia / immunology
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Microglia / metabolism
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Middle Aged
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Monocytes / immunology
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Monocytes / metabolism
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Multiple Sclerosis / cerebrospinal fluid*
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Multiple Sclerosis / diagnosis*
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Multiple Sclerosis / immunology
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Predictive Value of Tests
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Sensitivity and Specificity
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Time Factors
Substances
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Biomarkers
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Leukocyte L1 Antigen Complex