Abstract
Paneth cells are a small intestinal epithelial cell lineage that is considered to have a role in innate immune function. Recent studies on mice with diminished and/or loss of autophagy have suggested that Paneth cells are a primary target in vivo. Interestingly, loss of autophagy affects the secretion of antimicrobial proteins from Paneth cells. Understanding the intersection of the autophagy pathway with the secretory apparatus, which is a key feature of differentiation of Paneth cells, is a key unanswered question.
MeSH terms
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Animals
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Autophagy / physiology*
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Autophagy-Related Proteins
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Bodily Secretions / physiology
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Carrier Proteins / genetics
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Carrier Proteins / metabolism
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Cell Differentiation
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Crohn Disease / genetics
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Crohn Disease / immunology*
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Crohn Disease / pathology
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Genetic Predisposition to Disease
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Host-Pathogen Interactions
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Humans
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Intestine, Small / pathology
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Mice
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Paneth Cells / physiology*
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Polymorphism, Genetic
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Ribonuclease, Pancreatic / metabolism
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Toll-Like Receptors / metabolism
Substances
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ATG16L1 protein, human
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Autophagy-Related Proteins
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Carrier Proteins
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Toll-Like Receptors
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Ang4 protein, mouse
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Ribonuclease, Pancreatic