Jatrophalactam, a novel diterpenoid lactam isolated from Jatropha curcas

Org Lett. 2009 Dec 3;11(23):5522-4. doi: 10.1021/ol902349f.

Abstract

Jatrophalactam (1), a novel diterpenoid lactam possessing an unprecedented 5/13/3 tricyclic skeleton, was isolated from the roots of Jatropha curcas. The structure and relative configuration of jatrophalactam (1) were elucidated by extensive spectroscopic analysis and further determined by a single-crystal X-ray diffraction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallography, X-Ray
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology
  • Drug Screening Assays, Antitumor
  • Humans
  • Jatropha / chemistry*
  • Lactams / chemistry
  • Lactams / isolation & purification*
  • Lactams / pharmacology
  • Molecular Conformation
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Roots / chemistry

Substances

  • Diterpenes
  • Lactams