In Vitro Synergy of Levofloxacin Plus Piperacillin/Tazobactam against Pseudomonas aeruginosa

Vladimir Chachanidze; Aixa Curbelo-Irizarry; Deborah Ashcraft; George Pankey

doi:10.1155/2009/984934

In Vitro Synergy of Levofloxacin Plus Piperacillin/Tazobactam against Pseudomonas aeruginosa

Interdiscip Perspect Infect Dis. 2009:2009:984934. doi: 10.1155/2009/984934. Epub 2009 Nov 8.

Authors

Vladimir Chachanidze¹, Aixa Curbelo-Irizarry, Deborah Ashcraft, George Pankey

Affiliation

¹ Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA.

Abstract

In vitro synergy testing using levofloxacin (LVX) plus piperacillin/tazobactam (TZP) was performed by Etest and time-kill assay (TKA) for 31 unique fluoroquinolone-resistant Pseudomonas aeruginosa isolates. The Etest method showed synergy for 9/31 (29%) of isolates, while TKA showed synergy with 14/31 (45%) of isolates. When comparing the Etest method and TKA, concordant results for synergy, antagonism, and indifference were obtained for 24/31 (77%) of the isolates tested.