Objective: To explore the relation of cognition and uric acid in Parkinson's disease and analyze the related factors of cognition.
Methods: A total of 104 patients with Parkinson's disease were divided into two groups: those with cognitive impairment and those without. Every patient was subject to the cognitive and depression function assessment. And the fasting blood uric acid samples. Then the serum uric acid levels of two groups and analyze the related factors of the cognitive with multiple linear.
Results: (1) The serum uric acid level in the group with cognitive impairment (249 micromol/L +/- 59 micromol/L) is lower than that without cognitive impairment (323 micromol/L +/- 52 micromol/L), and there was marked statistical significance (t = -6.78, P < 0.001) (2) In PD patients, the cognitive scores correlated with serum uric acid levels, education, age, H-Y stages and the depression levels ,but didn't with gender,disease duration, smoking and BMI.
Conclusion: (1) There was correlation between the serum uric acid and the cognitive impairment. Low serum uric acid level predicted worse cognitive scores. (2) In PD, the change of the cognitive function was impacted by their education, age, H-Y stages and depression levels.