With the advances in interventional cardiology, percutaneous treatment by stenting has become a reasonable strategy in superior vena cava syndrome (SVCS), whether the underlying disease is malignant or benign. We present a 48-year-old woman with typical signs and symptoms of SVCS, who was treated with endovascular stenting by the percutaneous approach. We obtained both procedural success with complete restoration of blood flow and immediate relief of symptoms. During a follow-up period of six months, the patient was free of symptoms and computed tomography demonstrated complete stent patency.