Discovery of indolone acetamides as novel SV2A ligands with improved potency toward seizure suppression

ChemMedChem. 2010 Feb 1;5(2):200-5. doi: 10.1002/cmdc.200900436.
No abstract available

MeSH terms

  • Acetamides / chemistry*
  • Acetamides / pharmacokinetics
  • Animals
  • Anticonvulsants / chemistry*
  • Anticonvulsants / pharmacokinetics
  • Disease Models, Animal
  • Indoles / chemistry*
  • Levetiracetam
  • Ligands
  • Membrane Glycoproteins / antagonists & inhibitors
  • Membrane Glycoproteins / metabolism*
  • Mice
  • Nerve Tissue Proteins / antagonists & inhibitors
  • Nerve Tissue Proteins / metabolism*
  • Piracetam / analogs & derivatives
  • Piracetam / chemistry
  • Piracetam / pharmacology
  • Pyrrolidinones / chemistry
  • Pyrrolidinones / pharmacology
  • Rats
  • Seizures / drug therapy*
  • Synaptic Vesicles / metabolism

Substances

  • Acetamides
  • Anticonvulsants
  • Indoles
  • Ligands
  • Membrane Glycoproteins
  • Nerve Tissue Proteins
  • Pyrrolidinones
  • Seletracetam
  • Sv2a protein, mouse
  • Levetiracetam
  • brivaracetam
  • Piracetam