Preliminary report: Zn-alpha2-glycoprotein genotype and serum levels are associated with serum lipids

Louise E Olofsson; Bob Olsson; Theodore Lystig; Peter Jacobson; Margareta Jernås; Kajsa Sjöholm; Anders Gummesson; Lars Sjöström; Per Eriksson; Anders Hamsten; Laura P Hale; Dag S Thelle; Björn Carlsson; Lena M S Carlsson

doi:10.1016/j.metabol.2009.12.006

Preliminary report: Zn-alpha2-glycoprotein genotype and serum levels are associated with serum lipids

Metabolism. 2010 Sep;59(9):1316-8. doi: 10.1016/j.metabol.2009.12.006. Epub 2010 Jan 12.

Authors

Louise E Olofsson¹, Bob Olsson, Theodore Lystig, Peter Jacobson, Margareta Jernås, Kajsa Sjöholm, Anders Gummesson, Lars Sjöström, Per Eriksson, Anders Hamsten, Laura P Hale, Dag S Thelle, Björn Carlsson, Lena M S Carlsson

Affiliation

¹ The Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy at University of Gothenburg, 413 45 Gothenburg, Sweden.

PMID: 20070991
DOI: 10.1016/j.metabol.2009.12.006

Abstract

Zn-alpha2-glycoprotein (ZAG) is a serum protein implicated in cancer cachexia and lipolysis. Our aim was to investigate serum levels of ZAG and polymorphisms in the ZAG gene in relation to serum lipids in man. Serum levels of ZAG correlated with serum levels of cholesterol (P = .00088) in healthy subjects and during weight loss (P = .059). The ZAG genotype was associated with total cholesterol (P = .014) and low-density lipoprotein cholesterol (P = .026) in healthy subjects, and the associations were replicated in an additional cohort (P = .0017 and P = .060, respectively). Our data indicate that ZAG plays a role in lipid metabolism.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Female
Genetic Association Studies
Genotype
Humans
Immunoassay
Lipids / blood*
Male
Polymorphism, Genetic
Seminal Plasma Proteins / blood*
Seminal Plasma Proteins / genetics*
Zn-Alpha-2-Glycoprotein

Substances

Lipids
Seminal Plasma Proteins
Zn-Alpha-2-Glycoprotein