Genotoxicity of pyrene oxide and 1-nitropyrene oxides in hepatocyte primary culture/DNA repair test

Mutat Res. 1991 Apr;262(4):233-8. doi: 10.1016/0165-7992(91)90089-m.

Abstract

The genotoxicity of a pyrene oxide, 1-nitropyrene (NP) oxides and other related compounds was examined in the hepatocyte primary culture (HPC)/DNA repair test. Pyrene 4,5-oxide and both 1-NP-4,5-oxide and 1-NP-9,10-oxide elicited clearly positive responses of DNA repair. In this assay, 1-NP itself was weakly positive. However, other related chemicals such as pyrene, 1-nitro-3-hydroxypyrene, 1-nitro-6-hydroxypyrene, and 1-nitro-8-hydroxypyrene did not generate positive responses.

MeSH terms

  • Animals
  • Cells, Cultured
  • Cricetinae
  • Cricetulus
  • DNA Repair*
  • DNA, Bacterial / drug effects*
  • Liver / drug effects*
  • Liver / metabolism
  • Mutagenicity Tests
  • Pyrenes / toxicity*
  • Salmonella typhimurium / drug effects
  • Salmonella typhimurium / genetics

Substances

  • DNA, Bacterial
  • Pyrenes
  • 1-nitropyrene-9,10-oxide
  • pyrene 4,5-oxide