No Ljungan virus RNA in stool samples from the Norwegian environmental triggers of type 1 diabetes (MIDIA) cohort study

Diabetes Care. 2010 May;33(5):1069-71. doi: 10.2337/dc09-1951. Epub 2010 Feb 25.

Abstract

Objective: Ljungan virus (LjV) has been proposed as a potential environmental factor for type 1 diabetes. The objective was to test for any association of LjV with type 1 diabetes.

Research design and methods: A nested case-control design was used to test for any association between the development of pre-diabetic autoimmunity and presence of LjV in stool samples (n = 3,803) in the Norwegian Environmental Triggers of Type 1 Diabetes (MIDIA) study. The children followed were 27 infants who developed pre-diabetic autoimmunity during or shortly after the sampling period, 54 matched control subjects, and 94 other children.

Results: No LjV RNA was detected.

Conclusions: The results indicate that LjV is rare in young children. LjV does not seem to be involved in the development of human type 1 diabetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Cohort Studies
  • Diabetes Mellitus, Type 1 / epidemiology
  • Diabetes Mellitus, Type 1 / immunology*
  • Diabetes Mellitus, Type 1 / virology*
  • Environment
  • Feces / virology
  • Female
  • Humans
  • Male
  • Norway / epidemiology
  • Parechovirus / genetics
  • Parechovirus / immunology
  • Parechovirus / isolation & purification*
  • Picornaviridae Infections / complications*
  • Picornaviridae Infections / epidemiology
  • Picornaviridae Infections / immunology*
  • Prediabetic State / epidemiology
  • Prediabetic State / immunology
  • Prediabetic State / virology
  • RNA, Viral / genetics
  • Risk Factors
  • Young Adult

Substances

  • RNA, Viral