Abstract
The p62 protein recognizes toxic cellular waste, which is then scavenged by a sequestration process known as self-eating or autophagy. Lack of autophagy leads to accumulation of p62, which is not good for liver cells, as it induces a cellular stress response that leads to disease.
MeSH terms
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Adaptor Proteins, Signal Transducing / chemistry
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Adaptor Proteins, Signal Transducing / metabolism
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Adaptor Proteins, Signal Transducing / physiology*
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Animals
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Autophagy / physiology*
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Cytoskeletal Proteins / chemistry
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Cytoskeletal Proteins / metabolism
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Heat-Shock Proteins / chemistry
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Heat-Shock Proteins / physiology*
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Hepatocytes / metabolism
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Hepatocytes / pathology
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Kelch-Like ECH-Associated Protein 1
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Liver / metabolism
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Liver / pathology
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Liver / physiopathology
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Mice
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Models, Biological
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NF-E2-Related Factor 2 / metabolism
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Oxidative Stress / physiology
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Protein Binding / physiology
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Protein Interaction Domains and Motifs / physiology
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Sequestosome-1 Protein
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Signal Transduction / physiology
Substances
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Adaptor Proteins, Signal Transducing
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Cytoskeletal Proteins
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Heat-Shock Proteins
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Keap1 protein, mouse
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Kelch-Like ECH-Associated Protein 1
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NF-E2-Related Factor 2
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Nfe2l2 protein, mouse
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Sequestosome-1 Protein
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Sqstm1 protein, mouse