A small library of DNA-encapsulated supramolecular nanoparticles for targeted gene delivery

Chem Commun (Camb). 2010 Mar 21;46(11):1851-3. doi: 10.1039/b923711a. Epub 2010 Feb 11.

Abstract

We demonstrated a convenient, flexible and modular synthetic approach for preparation of a small library of DNA-encapsulated supramolecular nanoparticles SNPs superset DNA and RGD-SNPs superset DNA with different sizes and RGD target ligand coverage for targeted gene delivery.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cell Line
  • DNA / chemistry*
  • DNA / metabolism
  • Gene Transfer Techniques*
  • Humans
  • Mice
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure
  • Oligopeptides / chemistry
  • Oligopeptides / metabolism
  • Polyethylene Glycols / chemistry

Substances

  • Oligopeptides
  • Polyethylene Glycols
  • arginyl-glycyl-aspartic acid
  • DNA