Decreased quinolone susceptibility in high percentage of Enterobacter cloacae clinical isolates caused only by Qnr determinants

Xu Zhao; Xiaogang Xu; Demei Zhu; Xinyu Ye; Minggui Wang

doi:10.1016/j.diagmicrobio.2009.12.018

Decreased quinolone susceptibility in high percentage of Enterobacter cloacae clinical isolates caused only by Qnr determinants

Diagn Microbiol Infect Dis. 2010 May;67(1):110-3. doi: 10.1016/j.diagmicrobio.2009.12.018. Epub 2010 Mar 12.

Authors

Xu Zhao¹, Xiaogang Xu, Demei Zhu, Xinyu Ye, Minggui Wang

Affiliation

¹ Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, PR China.

PMID: 20227223
DOI: 10.1016/j.diagmicrobio.2009.12.018

Abstract

The prevalence of qnr genes was similar in the ciprofloxacin-resistant and ciprofloxacin-susceptible Enterobacter cloacae isolates, and no amino acid change in quinolone resistance-determining regions was found in any of the 21 qnr-positive but ciprofloxacin-susceptible strains. Qnr may thus be present before the development of higher-level resistance from target mutations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Substitution / genetics
Anti-Bacterial Agents / pharmacology*
Bacterial Proteins / genetics*
China / epidemiology
DNA, Bacterial / chemistry
DNA, Bacterial / genetics
Drug Resistance, Bacterial*
Enterobacter cloacae / drug effects*
Enterobacter cloacae / genetics*
Enterobacter cloacae / isolation & purification
Enterobacteriaceae Infections / epidemiology*
Enterobacteriaceae Infections / microbiology
Humans
Microbial Sensitivity Tests
Prevalence
Quinolones / pharmacology*

Substances

Anti-Bacterial Agents
Bacterial Proteins
DNA, Bacterial
Quinolones