The purpose of this case report was to present a method for assessing entire lower extremity performance and describe a Medical Exercise Therapy (MET) training program early after simultaneous bilateral total knee replacement (TKR). We also documented perceived function, mobility, and weight-bearing ability during functional tasks. The patient was a 50-year-old male who underwent a simultaneous bilateral procedure and began physical therapy (PT) 16 days postsurgery. Lower extremity performance (weight, repetitions, and load*volume) was assessed weekly using a one-legged horizontal press. Perceived physical abilities, mobility, and body weight placed over each limb during a sit to stand and a squat at two different flexion angles were assessed. At discharge load*volume for the weakest limb was 87% of the strongest side. At discharge, sit-to-stand, and 30 and 60 degree squat asymmetry ranged from 4% to 6%. Perceived abilities and mobility improved from initial visit to discharge. The patient was able to tolerate the closed-chain assessment of lower extremity performance and MET training program early after surgery. The patient made improvements in all functional tests and more importantly maintained a fairly equal distribution of body weight over both limbs during functional activities.