Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu

Nat Rev Mol Cell Biol. 2010 May;11(5):379-84. doi: 10.1038/nrm2885. Epub 2010 Apr 9.

Abstract

GW182 proteins have emerged as key components of microRNA (miRNA) silencing complexes in animals. Although the precise molecular function of GW182 proteins is not fully understood, new findings indicate that they act as poly(A)-binding protein (PABP)-interacting proteins (PAIPs) that promote gene silencing, at least in part, by interfering with cytoplasmic PABP1 (PABPC1) function during translation and mRNA stabilization. This recent discovery paves the way for future studies of miRNA silencing mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Autoantigens / chemistry
  • Autoantigens / metabolism*
  • Binding Sites
  • Gene Silencing
  • MicroRNAs / metabolism*
  • Molecular Sequence Data
  • Poly(A)-Binding Protein I / antagonists & inhibitors
  • Poly(A)-Binding Protein I / metabolism*
  • Protein Binding
  • Protein Structure, Tertiary

Substances

  • Autoantigens
  • MicroRNAs
  • Poly(A)-Binding Protein I

Associated data

  • PDB/2X04
  • PDB/3KUS