Patient specific 4D coronary models from ECG-gated CTA data for intra-operative dynamic alignment of CTA with X-ray images

Med Image Comput Comput Assist Interv. 2009;12(Pt 1):369-76. doi: 10.1007/978-3-642-04268-3_46.

Abstract

We present an approach to derive patient specific coronary models from ECG-gated CTA data and their application for the alignment of CTA with mono-plane X-ray imaging during interventional cardiology. A 4D (3D+t) deformation model of the coronary arteries is derived by (i) extraction of a 3D coronary model at an appropriate cardiac phase and (ii) non-rigid registration of the CTA images at different ECG phases to obtain a deformation model. The resulting 4D coronary model is aligned with the X-ray data using a novel 2D+t/3D+t registration approach. Model consistency and accuracy is evaluated using manually annotated coronary centerlines at systole and diastole as reference. Improvement of registration robustness by using the 2D+t/3D+t registration is successfully demonstrated by comparison of the actual X-ray cardiac phase with the automatically determined best matching phase in the 4D coronary model.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Artificial Intelligence
  • Cardiac-Gated Imaging Techniques / methods*
  • Computer Simulation
  • Coronary Angiography / methods*
  • Coronary Artery Disease / diagnostic imaging*
  • Electrocardiography / methods
  • Humans
  • Imaging, Three-Dimensional / methods*
  • Models, Anatomic
  • Models, Cardiovascular
  • Pattern Recognition, Automated / methods*
  • Radiographic Image Enhancement / methods
  • Radiographic Image Interpretation, Computer-Assisted / methods
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Subtraction Technique*
  • Tomography, X-Ray Computed / methods*