Urge incontinence: estimating environmental and obstetrical risk factors using an identical twin study

Int Urogynecol J. 2010 Aug;21(8):939-46. doi: 10.1007/s00192-010-1140-2. Epub 2010 May 6.

Abstract

Introduction and hypothesis: The objective of this study was to determine risk factors for urge urinary incontinence (UUI).

Methods: A multi-item survey was administered to a community sample of identical twin sisters from 2002-2008. Generalized estimating equations accounting for co-twin correlation were used to perform three different regression models on the outcome: UUI (yes vs. no).

Results: Mean age, median parity, and BMI were 41.4 +/- 16.4 (18-85), 1.0, and 26.0 +/- 6.5 (13.5-55.8), respectively. Thirty-five percent of women were post-menopausal, and 27.5% had UUI. Urge urinary incontinence was reported in 40.1% of parous versus 14.1% among nulliparous women (p < .0001). The rate of UUI was 40.6% after vaginal delivery, 36.7% after cesarean delivery, and 14.1% in nulliparous women (p < .0001). Obesity, age >40, and chronic constipation were also identified as risk factors for urge urinary incontinence.

Conclusion: Risk factors for UUI include parity, age, obesity, and chronic constipation. There was a 2.5-fold increased risk of UUI after one or more births, regardless of type of delivery.

Publication types

  • Twin Study

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Chronic Disease
  • Constipation / complications*
  • Cross-Sectional Studies
  • Delivery, Obstetric / methods
  • Female
  • Health Surveys
  • Humans
  • Middle Aged
  • Obesity / complications*
  • Parity*
  • Pregnancy
  • Regression Analysis
  • Risk Factors
  • Twins, Monozygotic*
  • Urinary Incontinence, Urge / epidemiology*
  • Young Adult