The role of vitamin D in multiple sclerosis

Margitta T Kampman; Linn H Steffensen

doi:10.1016/j.jphotobiol.2010.04.003

The role of vitamin D in multiple sclerosis

J Photochem Photobiol B. 2010 Nov 3;101(2):137-41. doi: 10.1016/j.jphotobiol.2010.04.003. Epub 2010 Apr 21.

Authors

Margitta T Kampman¹, Linn H Steffensen

Affiliation

¹ University Hospital of North Norway, Department of Neurology, P.O. Box 6060, 9038 Tromsø, Norway. margitta.kampman@unn.no

PMID: 20471852
DOI: 10.1016/j.jphotobiol.2010.04.003

Abstract

Multiple sclerosis (MS) risk is determined by environmental influences acting on the individual genetic background. Recent epidemiologic and experimental evidence supports a role of low environmental supplies of vitamin D in mediating an increased susceptibility to MS. We review available evidence suggesting that vitamin D status may influence MS risk and even modulate clinical disease activity. The level of serum 25-hydroxyvitamin D providing these effects remains to be determined.

Publication types

Review

MeSH terms

Clinical Trials as Topic
HLA-DR Antigens / genetics
HLA-DRB1 Chains
Humans
Multiple Sclerosis / etiology*
Multiple Sclerosis / genetics
Multiple Sclerosis / prevention & control
Risk Factors
Sex Factors
Ultraviolet Rays
Vitamin D / analogs & derivatives*
Vitamin D / blood
Vitamin D / physiology*

Substances

HLA-DR Antigens
HLA-DRB1 Chains
HLA-DRB1*15 antigen
Vitamin D
25-hydroxyvitamin D