Legislative decree n.81 of 9 April 2008--promulgated pursuant to article 1 of law n. 123 dated 3 August 2007 and amended by Legislative Decree n. 106 of 3 August 2009--is the legislative text that changed the field of health and safety at work. This Text represents the mainstream of national legislation to protect workers against work's diseases. The B-BS system is a technique based on scientific disciplines that allows to modify behaviors related to safety, to reduce the influence of the human error component in the dynamics of most accidents. The aim of this article is to make a comparison between the requirements outlined by D.lgs. 106/09 and the implementation of protocols for B-BS in business, highlighting critical issues and possible contact points. Although it is strictly necessary to apply the legislative decree by the companies, it is also important for the workers to perform safe behaviors, according to the same dictates of legislation. For this reason it is essential to analyze the compatibilities between the legislative text (D.lgs 106/09) and the B-BS system, to create a multidisciplinary culture of safety and to build safer and healthier work environments.