One-step synthesis of diarylpyrazolo[3,4-b]pyridines from isoflavones

Zun-Ting Zhang; Yong Liang; Yu-Qing Ma; Dong Xue; Jun-Ling Yang

doi:10.1021/cc1000506

One-step synthesis of diarylpyrazolo[3,4-b]pyridines from isoflavones

J Comb Chem. 2010 Jul 12;12(4):600-3. doi: 10.1021/cc1000506.

Authors

Zun-Ting Zhang¹, Yong Liang, Yu-Qing Ma, Dong Xue, Jun-Ling Yang

Affiliation

¹ Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, PR China. zhangzt@snnu.edu.cn

PMID: 20524639
DOI: 10.1021/cc1000506

Abstract

A new concise, facile, and efficient method for the synthesis of 3-hydroxy-5,6-diphenylpyrazolo[3,4-b]pyridine derivatives has been described. The cyclocondensation of isoflavones with 3-amino-5-hydroxypyrazole in the presence of sodium methoxide gave fused heteroaromatic 3-hydroxy-5,6-diphenylpyrazolo[3,4-b]pyridines in moderate to good yields.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Combinatorial Chemistry Techniques*
Crystallography, X-Ray
Isoflavones / chemistry*
Models, Molecular
Molecular Structure
Pyrazoles / chemical synthesis*
Pyrazoles / chemistry
Pyridines / chemical synthesis*
Pyridines / chemistry
Small Molecule Libraries
Stereoisomerism

Substances

Isoflavones
Pyrazoles
Pyridines
Small Molecule Libraries
pyrazolo(3,4-b)pyridine