In vitro synergistic/additive activity of levofloxacin with meropenem against Stenotrophomonas maltophilia

Diagn Microbiol Infect Dis. 2010 Jul;67(3):297-300. doi: 10.1016/j.diagmicrobio.2010.02.015.

Abstract

Synergy testing of levofloxacin and meropenem by Etest and time-kill assay (TKA) was performed against 30 genetically unique clinical Stenotrophomonas maltophilia isolates. Synergy was demonstrated in 18/30 (60%) isolates by Etest and in 13/30 (43%) by TKA; the remaining isolates were indifferent. Methods showed agreement for 25/30 (83%) of isolates.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Drug Synergism
  • Humans
  • Levofloxacin*
  • Meropenem
  • Microbial Sensitivity Tests
  • Microbial Viability / drug effects
  • Ofloxacin / pharmacology*
  • Stenotrophomonas maltophilia / drug effects*
  • Thienamycins / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Thienamycins
  • Levofloxacin
  • Ofloxacin
  • Meropenem