Abstract
Various antioxidant strategies such as supplementation of antioxidants, limiting oxygen concentration with Oxyrase, and reducing reactive oxygen species through mild mitochondrial uncoupling had statistically significant beneficial effects on sperm cryopreservation from rhesus monkeys with low cryoresistant ejaculates. Individuals or species that have higher sensitivity to cryodamage may derive the most benefit from these treatments.
Copyright © 2010. Published by Elsevier Inc.
Publication types
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Evaluation Study
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Research Support, N.I.H., Extramural
MeSH terms
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2,4-Dinitrophenol / pharmacology*
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Animals
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Antioxidants / pharmacology*
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Cell Survival / drug effects
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Cryopreservation / methods
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Ejaculation / physiology
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Freezing
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Macaca mulatta* / metabolism
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Macaca mulatta* / physiology
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Male
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Mitochondria / drug effects
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Mitochondria / metabolism
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Oxygenases / pharmacology*
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Reactive Oxygen Species / metabolism
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Semen Analysis
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Semen Preservation / methods
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Spermatozoa / drug effects*
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Spermatozoa / metabolism
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Spermatozoa / physiology
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Uncoupling Agents / pharmacology
Substances
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Antioxidants
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Reactive Oxygen Species
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Uncoupling Agents
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Oxygenases
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Oxyrase
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2,4-Dinitrophenol