Abstract
The effects of the challenge dose and major histocompatibility complex (MHC) class IB alleles were analyzed in 112 Mauritian cynomolgus monkeys vaccinated (n = 67) or not vaccinated (n = 45) with Tat and challenged with simian/human immunodeficiency virus (SHIV) 89.6P(cy243.) In the controls, the challenge dose (10 to 20 50% monkey infectious doses [MID(50)]) or MHC did not affect susceptibility to infection, peak viral load, or acute CD4 T-cell loss, whereas in the chronic phase of infection, the H1 haplotype correlated with a high viral load (P = 0.0280) and CD4 loss (P = 0.0343). Vaccination reduced the rate of infection acquisition at 10 MID(50) (P < 0.0001), and contained acute CD4 loss at 15 MID(50) (P = 0.0099). Haplotypes H2 and H6 were correlated with increased susceptibility (P = 0.0199) and resistance (P = 0.0087) to infection, respectively. Vaccination also contained CD4 depletion (P = 0.0391) during chronic infection, independently of the challenge dose or haplotype.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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AIDS Vaccines / administration & dosage
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AIDS Vaccines / immunology
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Animals
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Disease Models, Animal
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Dose-Response Relationship, Immunologic
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HIV / immunology*
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HIV Infections / genetics*
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HIV Infections / immunology*
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HIV Infections / prevention & control
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HIV Infections / virology
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Haplotypes
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Histocompatibility Antigens Class I / genetics*
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Histocompatibility Antigens Class I / immunology
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Humans
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Macaca fascicularis
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Simian Acquired Immunodeficiency Syndrome / genetics*
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Simian Acquired Immunodeficiency Syndrome / immunology*
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Simian Acquired Immunodeficiency Syndrome / prevention & control
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Simian Acquired Immunodeficiency Syndrome / virology
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Simian Immunodeficiency Virus / immunology*
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Vaccination
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Viral Load
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tat Gene Products, Human Immunodeficiency Virus / administration & dosage
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tat Gene Products, Human Immunodeficiency Virus / genetics
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tat Gene Products, Human Immunodeficiency Virus / immunology*
Substances
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AIDS Vaccines
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Histocompatibility Antigens Class I
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tat Gene Products, Human Immunodeficiency Virus