Were determined components of systems of guarantee of security of activity of specialists of manipulation of spacecrafts (SC): abidance by general organizational-methodological rules and principles of work, excluding violations in organization of duty, preventing of nonfulfillment and failure of sessions of control by SC, determination and deleting negative factors of operative activity, guarantee of safety of system "man-mechanism-environment." Were determined peculiarities of activity of specialists of manipulation of spacecrafts, their professionally important qualities, which had to be considered in effectuating of professional psycho-selection. Were shown regularities of changes in functional state and professional working capacity of operators of command-measured complexes during daily duty and during cycle of a year. Was made a conclusion about necessity of improvement of system of psychophysiological accompaniment of activity of specialists of manipulation of SC.