Nearly 30 million people have died of AIDS during the past 27 years. More than 90% of people with HIV live in the developing world. The virus does not discriminate by age, race, gender, ethnicity, sexual orientation, or socioeconomic status-anyone is susceptible. HIV/AIDS has been particularly devastating on women and girls who now comprise more than 50% of people aged 15 years and older living with HIV. Successful strategies with significant impact on new HIV infections include strong governmental support, voluntary counseling and treatment, harm-reduction, community outreach, and universal access to treatment. This study presents the results of educational and social structural/environmental behavioral interventions among young women and their male partners. A 10-year study among high-risk populations (female bar workers and their male customers) in the Philippines identifies major components of a model HIV prevention program.