Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis

J Neuroimmunol. 2010 Oct 8;227(1-2):162-6. doi: 10.1016/j.jneuroim.2010.06.003. Epub 2010 Jul 2.

Abstract

In a genome wide association study consisting of 592 German multiple sclerosis (MS) patients and 825 controls we were able to replicate the association of the HLA region with MS independently of previous case control studies. No SNPs outside the HLA region reached a genome wide level of significance. Nevertheless, we found suggestive evidence for an association of MS with variants in two new genes, the VAV2 gene and the gene for ZNF433.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Case-Control Studies
  • Female
  • Genetic Predisposition to Disease / genetics*
  • Genome-Wide Association Study / methods
  • HLA Antigens / genetics
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis / epidemiology
  • Multiple Sclerosis / genetics*
  • Multiple Sclerosis / metabolism*
  • Polymorphism, Single Nucleotide / genetics
  • Proto-Oncogene Proteins c-vav / genetics*
  • Repressor Proteins / genetics*
  • Young Adult
  • Zinc Fingers / genetics*
  • Zinc Fingers / immunology*

Substances

  • HLA Antigens
  • Proto-Oncogene Proteins c-vav
  • Repressor Proteins
  • VAV2 protein, human
  • ZNF433 protein, human