Abstract
There is evolving interest in the use of mesenchymal stem cells (MSC) in solid organ transplantation. Pre-clinical transplantation models show efficacy of MSC in prolonging graft survival and a number of clinical studies are planned or underway. At a recent meeting of the MISOT consortium (MSC In Solid Organ Transplantation) the advances of these studies were evaluated and mechanisms underlying the potential effects of MSC discussed. Continued discussion is required for definition of safety and eventually efficacy endpoints for MSC therapy in solid organ transplantation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Culture Techniques
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Cell- and Tissue-Based Therapy / methods
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Graft Survival / physiology*
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Humans
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Immunophenotyping
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Immunosuppression Therapy / methods
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Kidney Transplantation / immunology
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Kidney Transplantation / physiology
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Liver Transplantation / immunology
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Liver Transplantation / physiology
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Mesenchymal Stem Cell Transplantation / methods*
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Mesenchymal Stem Cells / cytology
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Mesenchymal Stem Cells / immunology
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Mesenchymal Stem Cells / physiology
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Organ Transplantation / methods*
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Organ Transplantation / physiology
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Safety
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T-Lymphocytes / immunology