New peptides isolated from Lyngbya species: a review

Mar Drugs. 2010 Jun 9;8(6):1817-37. doi: 10.3390/md8061817.

Abstract

Cyanobacteria of the genus Lyngbya have proven to be prodigious producers of secondary metabolites. Many of these compounds are bioactive and show potential for therapeutic use. This review covers peptides and hybrid polyketide-non-ribosomal peptides isolated from Lyngbya species. The structures and bioactivities of 50 Lyngbya peptides which were reported since 2007 are presented.

Keywords: Lyngbya; bioactivity; cyanobacteria; peptide; secondary metabolites.

Publication types

  • Review

MeSH terms

  • Bacterial Proteins / chemistry
  • Bacterial Proteins / isolation & purification
  • Bacterial Proteins / metabolism*
  • Bacterial Proteins / pharmacology
  • Cyanobacteria / metabolism*
  • Depsipeptides / chemistry
  • Depsipeptides / isolation & purification
  • Depsipeptides / metabolism
  • Depsipeptides / pharmacology
  • Drug Discovery*
  • Lipopeptides / chemistry
  • Lipopeptides / isolation & purification
  • Lipopeptides / metabolism
  • Lipopeptides / pharmacology
  • Lyngbya Toxins / chemistry
  • Lyngbya Toxins / isolation & purification
  • Lyngbya Toxins / metabolism
  • Lyngbya Toxins / pharmacology
  • Peptides / chemistry
  • Peptides / isolation & purification
  • Peptides / metabolism*
  • Peptides / pharmacology
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / isolation & purification
  • Peptides, Cyclic / metabolism
  • Peptides, Cyclic / pharmacology
  • Protease Inhibitors / chemistry
  • Protease Inhibitors / isolation & purification
  • Protease Inhibitors / metabolism
  • Protease Inhibitors / pharmacology

Substances

  • Bacterial Proteins
  • Depsipeptides
  • Lipopeptides
  • Lyngbya Toxins
  • Peptides
  • Peptides, Cyclic
  • Protease Inhibitors