Abstract
Cyanobacteria of the genus Lyngbya have proven to be prodigious producers of secondary metabolites. Many of these compounds are bioactive and show potential for therapeutic use. This review covers peptides and hybrid polyketide-non-ribosomal peptides isolated from Lyngbya species. The structures and bioactivities of 50 Lyngbya peptides which were reported since 2007 are presented.
Keywords:
Lyngbya; bioactivity; cyanobacteria; peptide; secondary metabolites.
MeSH terms
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Bacterial Proteins / chemistry
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Bacterial Proteins / isolation & purification
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Bacterial Proteins / metabolism*
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Bacterial Proteins / pharmacology
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Cyanobacteria / metabolism*
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Depsipeptides / chemistry
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Depsipeptides / isolation & purification
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Depsipeptides / metabolism
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Depsipeptides / pharmacology
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Drug Discovery*
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Lipopeptides / chemistry
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Lipopeptides / isolation & purification
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Lipopeptides / metabolism
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Lipopeptides / pharmacology
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Lyngbya Toxins / chemistry
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Lyngbya Toxins / isolation & purification
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Lyngbya Toxins / metabolism
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Lyngbya Toxins / pharmacology
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Peptides / chemistry
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Peptides / isolation & purification
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Peptides / metabolism*
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Peptides / pharmacology
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / isolation & purification
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Peptides, Cyclic / metabolism
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Peptides, Cyclic / pharmacology
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Protease Inhibitors / chemistry
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Protease Inhibitors / isolation & purification
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Protease Inhibitors / metabolism
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Protease Inhibitors / pharmacology
Substances
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Bacterial Proteins
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Depsipeptides
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Lipopeptides
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Lyngbya Toxins
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Peptides
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Peptides, Cyclic
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Protease Inhibitors