Management of chronic hepatitis B in pregnancy

Clin Liver Dis. 2010 Aug;14(3):495-504. doi: 10.1016/j.cld.2010.05.008.

Abstract

Providing appropriate treatment and follow-up to hepatitis B virus (HBV)-infected mothers and their newborns is critical in preventing HBV mother-to-child transmission (MTCT) and eradicating HBV infection. Although highly effective in preventing MTCT, standard passive-active immunoprophylaxis with hepatitis B immunoglobulin and the hepatitis B vaccine may have a failure rate as high as 10% to 15%. Antiviral treatment has been used during pregnancy and may decrease MTCT. Several issues must be addressed in future clinical studies before universal recommendations for antiviral therapy for pregnant women can be made.

MeSH terms

  • Antiviral Agents / therapeutic use
  • Female
  • Hepatitis B Surface Antigens / immunology
  • Hepatitis B Vaccines / therapeutic use
  • Hepatitis B virus / drug effects
  • Hepatitis B virus / immunology
  • Hepatitis B* / congenital
  • Hepatitis B* / drug therapy
  • Hepatitis B* / epidemiology
  • Hepatitis B* / prevention & control
  • Humans
  • Immunoglobulins / therapeutic use
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical / prevention & control*
  • Pregnancy
  • Pregnancy Complications, Infectious* / drug therapy
  • Pregnancy Complications, Infectious* / epidemiology
  • Pregnancy Complications, Infectious* / prevention & control
  • Pregnancy Complications, Infectious* / virology

Substances

  • Antiviral Agents
  • Hepatitis B Surface Antigens
  • Hepatitis B Vaccines
  • Immunoglobulins
  • hepatitis B hyperimmune globulin