Multicolored redox active upconverter cerium oxide nanoparticle for bio-imaging and therapeutics

Chem Commun (Camb). 2010 Oct 7;46(37):6915-7. doi: 10.1039/c0cc01832e. Epub 2010 Aug 4.

Abstract

Cytocompatible, co-doped cerium oxide nanoparticles exhibited strong upconversion properties that were found to kill lung cancer cells by inducing apoptosis thereby demonstrating the potential to be used as clinical contrast agents for imaging and as therapeutic agents for treatment of cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Cerium / chemistry
  • Cerium / pharmacology*
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Endothelial Cells / drug effects*
  • Humans
  • Nanoparticles / chemistry*
  • Oxidation-Reduction
  • Particle Size
  • Surface Properties

Substances

  • Antineoplastic Agents
  • Cerium
  • ceric oxide