Abstract
The asymmetric total synthesis of the polyprenylated acylphloroglucinol hyperibone K has been achieved using an enantioselective alkylative dearomatization-annulation process. NMR and computational studies were employed to probe the mode of action of a chiral phase-transfer (ion pair) catalyst.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adamantane / analogs & derivatives*
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Adamantane / chemical synthesis
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Adamantane / chemistry
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Alkylation
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Catalysis
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Crystallography, X-Ray
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Hemiterpenes / chemical synthesis*
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Hemiterpenes / chemistry
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Models, Molecular
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Molecular Structure
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Phloroglucinol / analogs & derivatives*
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Phloroglucinol / chemical synthesis*
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Phloroglucinol / chemistry
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Stereoisomerism
Substances
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Hemiterpenes
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hyperibone K
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Phloroglucinol
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Adamantane