Inactivating GGTase-I reduces disease phenotypes in a mouse model of K-RAS-induced myeloproliferative disease

Leukemia. 2011 Jan;25(1):186-9. doi: 10.1038/leu.2010.242. Epub 2010 Oct 26.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkyl and Aryl Transferases / antagonists & inhibitors*
  • Alkyl and Aryl Transferases / genetics
  • Alkyl and Aryl Transferases / physiology
  • Animals
  • Disease Models, Animal
  • Enzyme Inhibitors / therapeutic use*
  • Genes, ras*
  • Mice
  • Myeloproliferative Disorders / drug therapy*
  • Myeloproliferative Disorders / enzymology
  • Phenotype
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy

Substances

  • Enzyme Inhibitors
  • Alkyl and Aryl Transferases
  • geranylgeranyltransferase type-I