Metabolic-targeted therapy with dichloroacetate (DCA): a novel treatment strategy to improve the outcome of photodynamic therapy

Photochem Photobiol Sci. 2011 Jan;10(1):25-8. doi: 10.1039/c0pp00193g. Epub 2010 Oct 26.

Abstract

For the first time we present data showing that metabolic targeted therapy with dichloroacetate (DCA) may improve the outcome of photodynamic therapy. This treatment modality can be easily introduced into clinical practice guidelines.

MeSH terms

  • Cell Line, Tumor
  • Dichloroacetic Acid / therapeutic use*
  • Dichloroacetic Acid / toxicity
  • Humans
  • Light
  • Neoplasms / drug therapy*
  • Neoplasms / metabolism
  • Photochemotherapy*
  • Photosensitizing Agents / therapeutic use
  • Photosensitizing Agents / toxicity
  • Phthalic Acids / therapeutic use
  • Phthalic Acids / toxicity

Substances

  • Photosensitizing Agents
  • Phthalic Acids
  • 5-aminoisophthalic acid
  • Dichloroacetic Acid