Reversing the hemoglobin switch

N Engl J Med. 2010 Dec 2;363(23):2258-60. doi: 10.1056/NEJMcibr1010767.

Authors

Vijay G Sankaran¹, David G Nathan

Affiliation

¹ Children's Hospital Boston, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, USA.

PMID: 21121839
DOI: 10.1056/NEJMcibr1010767

No abstract available

MeSH terms

Animals
Carrier Proteins / genetics*
Carrier Proteins / metabolism
Codon, Nonsense
Fetal Hemoglobin / genetics*
Fetal Hemoglobin / metabolism
Gene Expression Regulation, Developmental*
Genes, Switch
Hemoglobins / genetics*
Hemoglobins / metabolism
Humans
Kruppel-Like Transcription Factors / genetics
Kruppel-Like Transcription Factors / physiology*
Mice
Models, Animal
Nuclear Proteins / genetics*
Nuclear Proteins / metabolism
Repressor Proteins
beta-Globins / biosynthesis

Substances

BCL11A protein, human
Carrier Proteins
Codon, Nonsense
Hemoglobins
Kruppel-Like Transcription Factors
Nuclear Proteins
Repressor Proteins
beta-Globins
erythroid Kruppel-like factor
Fetal Hemoglobin