L-threodops increases extracellular norepinephrine levels in the brain: an in vivo study

Neurology. 1990 Jul;40(7):1134-5. doi: 10.1212/wnl.40.7.1134.

Abstract

Extracellular norepinephrine levels in the striatum of normal rats increased significantly following the administration of L-threodops. When peripheral decarboxylase activity was inhibited with carbidopa, administration of the same dose of L-threodops induced a 2.5-fold greater increase in norepinephrine levels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carbidopa / pharmacology
  • Corpus Striatum / analysis*
  • Droxidopa / pharmacology*
  • Extracellular Space / analysis
  • Male
  • Norepinephrine / analysis*
  • Rats
  • Rats, Inbred Strains
  • Serine / analogs & derivatives*

Substances

  • Serine
  • Droxidopa
  • Carbidopa
  • Norepinephrine