Abstract
Extracellular norepinephrine levels in the striatum of normal rats increased significantly following the administration of L-threodops. When peripheral decarboxylase activity was inhibited with carbidopa, administration of the same dose of L-threodops induced a 2.5-fold greater increase in norepinephrine levels.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Carbidopa / pharmacology
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Corpus Striatum / analysis*
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Droxidopa / pharmacology*
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Extracellular Space / analysis
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Male
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Norepinephrine / analysis*
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Rats
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Rats, Inbred Strains
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Serine / analogs & derivatives*
Substances
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Serine
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Droxidopa
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Carbidopa
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Norepinephrine